Chemical & Physical Properties:
CAS NO: 15318-45-3
Molecular Formular: C12H15Cl2NO5S
MW: 356.22
EINECS: 239-355-3
HS Code:
Melting point : 163-166 °C
storage temp.: -20°C Freezer, Under Inert Atmosphere
Items | Specification |
Description | White to off-white crystalline powder or crystal |
Melting Point | 163-166°C |
Mor file | 15318-45-3.mol |
Merck | 14,9301 |
Safety Statements | 22-24/25 |
Purity | 98%min |
Water Solubility:
Soluble in acetonitrile or DMF. Slightly soluble in water.
Application
Thiamphenicol (also known as thiophenicol and dextrosulphenidol) is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, it is insoluble in water, but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.
Thiamphenicol is also widely used in Brazil, particularly for the treatment of sexually transmitted infections and pelvic inflammatory disease.
Unlike chloramphenicol, thiamphenicol is is not readily metabolized in cattle, poultry, sheep, or humans, but is predominantly excreted unchanged. In pigs and rats the drug is excreted both as parent drug and as thiamphenicol glucuronate.
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